Description
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.
As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Pharmaceutical Product R&DJob Category:
Scientific/TechnologyAll Job Posting Locations:
Beerse, Antwerp, BelgiumJob Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
Job Description:
Within Johnson & Johnson Innovative Medicine, we are recruiting a Senior/Principal Scientist with strong skills in High-resolution mass spectrometry – based structure elucidation.
Johnson & Johnson Innovative Medicine develops treatments that improve the health and lifestyles of people worldwide. Our development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, pulmonary hypertension and reproductive medicine. The successful candidate will be employed in our Analytical Development (AD) organization, responsible for Global Therapeutics Development and Supply (TDS) Organization.
The (Senior) Scientist will join the Advanced Materials Characterization and Investigations (AMCI) group within AD. AMCI is an international and diverse, multidisciplinary team of scientists leading advanced characterization and mechanistical understanding of our drug substances and drug products. We are also leading analytical investigations for commercial and R&D portfolio.
Within AMCI, the Advanced Molecular Analysis (AMA) team is a group of analytical centers of excellence in structure elucidation (by high-resolution mass spectrometry and NMR), organic and inorganic trace analysis, polymer characterization, and Antibody-drug conjugate (ADC), oligonucleotide & peptide analytics.
We are currently seeking a skilled and enthusiastic scientist with a strong background in high-resolution mass spectrometry (HRMS) to join our AMA team, where you will play a crucial role the identification of process impurities and degradation products of our synthetic molecule portfolio. This laboratory-based position offers you the opportunity to lead the development, implementation, and execution of innovative analytical test methods for several types of active pharmaceutical ingredients like (cyclic) peptides, oligonucleotides, ADCs as well as traditional small molecules. In this role, you will also collaborate closely with internal and external specialists to conduct thorough root-cause investigations and explore innovative approaches for optimal analyses and characterization. If you are passionate about pushing the boundaries of analytical techniques and eager to make a significant impact in the field, we would love to hear from you!
The position is based in Antwerp (Beerse), Belgium.
Key Responsibilities:
- Design and develop advanced (High Resolution) Mass Spectrometry-based methods for structure elucidation of diverse active pharmaceutical ingredients., with a potential emphasis on peptides and oligonucleotides.
- Take the lead/assist in the development of databases, spectral libraries and in silico tools to facilitate MS-based structure elucidation
- Apply state-of-the art scientific knowledge to ensure high-quality of the delivered results.
- Work in a multidisciplinary team of scientists and show the ability to learn and explore new analytical techniques.
- Maintain a safe work environment in compliance with all applicable environmental, health, regulatory requirements, GMP and safety regulations.
- Independently troubleshoot diverse mass spectrometers.
- Lead comprehensive root cause investigations related to MS-based structure elucidation of compounds within our R&D and commercial portfolio.
- Stay abreast with scientific knowledge to guarantee the delivery of high-quality results, strengthening our position as leaders in mass spectrometry-based structure elucidation.
- Initiate and lead partnerships with universities and other research institutions to expand our external innovation network, fostering collaboration that enhances our capabilities and expertise.
Qualifications
- A PhD degree in analytical chemistry or related field; or a master’s degree in related science with a minimum of 6 years of experience. Work-related experience in pharmaceutical R&D is an asset.
- Proven in-depth and hands-on expertise in high-resolution mass spectrometry is essential for this role, particularly with a focus on MS-based structure elucidation.
- Experience with coding, programming and the use of in silico tools to assist structure elucidation is a clear plus.
- Working experience with mass spectrometry of (cyclic) peptides, oligonucleotides and/or ADCs is an advantage.
- Hands-on experience with advanced hyphenated separation technology such as capillary electrophoresis (CE) or multidimensional liquid chromatography is an asset.
- Knowledge of regulatory frameworks (e.g., ICH, EMA, FDA) and GMP guidelines, particularly concerning validation requirements, is an advantage.
- Excellent English communication skills, both written and spoken, allowing for effective scientific discussions and collaboration.
Our offer
An exciting position in an international and dynamic environment with continuous learning and growth opportunities! An attractive remuneration package with additional benefit packages (for example hospital insurance, and other health care incentives if applicable). An inclusive team environment where diversity and different opinions are respected and valued, and the importance of a good work-life balance is recognized.
Required Skills:
Preferred Skills:
Mass Spectrometry (MS), Mass Spectrometry AnalysisThe anticipated base pay range for this position is:
€72,500.00 - €115,230.00Benefits:
In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.
*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.
