This job posting is anticipated to close on Jun 04 2026. We may however extend this time period, in which case the posting will remain available on www.careers.jnj.com to accept additional applications.
Description
At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.
As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
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Post Doc – R&D Product DevelopmentJob Category:
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Spring House, Pennsylvania, United States of AmericaJob Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
Learn more at https://www.jnj.com/innovative-medicine
We are searching for the best talent for a Postdoctoral Scholar, Bioanalytical Discovery & Development Sciences to be located in Spring House, PA.
Purpose: The Bioanalytical Discovery and Development Sciences (BDDS) department within Johnson & Johnson’s Preclinical Sciences & Translational Safety (PSTS) organization seeks a postdoctoral scholar to develop and validate an open, amplification-coupled immunoaffinity platform for reliable quantification of low-abundance protein biomarkers using standard laboratory equipment. The role addresses key analytical gaps in next-generation therapeutics by delivering fit-for-purpose assays, validation-ready documentation, and transferable methods to support PK/TE/biomarker decisions and translational studies.
This hands-on role includes assay and reagent design, systematic optimization, analytical characterization, benchmarking against orthogonal and commercial platforms, and preparation of SOPs and tech-transfer materials. The postdoc will collaborate with PK/PD and translational teams, communicate results through reports and publications, and help expand the use of ultrasensitive assays in preclinical and clinical programs.
You will be responsible for:
- Leading the design, development, and optimization of ultra-sensitive, amplification coupled immunoaffinity assays to enable reliable quantification of low abundance biomarkers (targeting sensitivity down to fg/mL) using standard laboratory instrumentation.
- Leading head‑to‑head benchmarking of in‑house assays against orthogonal methods (LBA, LC‑MS) and commercial ultra‑sensitive platforms to compare LOD/LLOQ, precision, sample requirements, and tech‑transfer readiness.
- Collaborating with cross‑functional teams (PK/PD, bioinformatics, translational science, and external partners) to integrate biomarker data into study design and decision making, and to benchmark methods against orthogonal platforms.
- Producing and maintaining clear technical documentation, including Standard Operating Procedures (SOPs), reagent quality control (QC) criteria, validation plans/reports, and method transfer packages to support reproducibility and technology dissemination.
- Communicating findings through written reports, presentations, and contributions to manuscripts; providing training and technical support for method transfer and laboratory adoption.
Qualifications/Requirements
Education:
- A PhD in Molecular Biology, Bioengineering, Biochemistry, Immunology, Analytical Chemistry, or a related field is required.
Experience and Skills:
Required:
- Hands‑on experience developing and optimizing immunoassays or nucleic‑acid amplification assays (e.g., qPCR, digital PCR, NGS) is required.
- Practical knowledge of Immuno‑PCR, proximity ligation/extension strategies, or related amplification‑coupled immunoaffinity techniques is required.
- Strong molecular biology skills: PCR/qPCR assay design and optimization, UMI/barcode strategies, NGS library preparation workflows, template purification and contamination control is required.
- Excellent written and verbal communication skills are required.
- Ability to work in cross-functional teams and present technical results to diverse audiences is required.
Preferred:
- Familiarity with antibody/protein engineering, including optimizing affinity, stability, fragment design, and tagging, which directly enhances assay sensitivity and minimizes off-target binding is preferred.
- Prior experience measuring CNS biomarkers (e.g., tau species, neurodegeneration biomarkers) or working with low‑abundance protein analytes is preferred.
- Familiarity with bioanalytical platforms for ultrasensitive detection and an understanding of their strengths/limitations is preferred.
- Knowledge of PK/PD/TE study design as well as assay validation and how bioanalytical data informs translational decision making is preferred.
- Hands on experience with electronic lab notebook (ELN) systems and laboratory informatics platforms for experiment documentation, reagent/inventory tracking, and maintaining data integrity (e.g., commercial ELNs and signals style lab notebook systems) is preferred.
Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.
Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via https://www.jnj.com/contact-us/careers, internal employees contact AskGS to be directed to your accommodation resource.
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Required Skills:
Preferred Skills:
